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|Title:||Analysis of toxicity effects from molecular to population level: Circadian oscillator case study|
|Authors:||ZALDIVAR COMENGES Jose'|
|Citation:||The Open Journal of Toxicology vol. 4 p. 1-12|
|Publisher:||Bentham Science Publishers|
|JRC Publication N°:||JRC54858|
|Type:||Articles in Journals|
|Abstract:||To analyze how toxic effects propagate from molecular to population level, a simple model of a circadian oscillator has been coupled with a cyanobacteria growth model. It has been assumed that the circadian oscillator synchronizes with light-dark environmental conditions and toxicants affect this synchronization reducing the population growth. Then dose-response curves have been developed. The results evidence that to understand toxic effects we have to focus our study on the interactions that a certain compound may have with proteins, and/or DNA, since the result of these interactions will determine the final mode of action at macroscopic level. Therefore an intermediate step for assessing toxic effects has been proposed.|
|JRC Institute:||Institute for Health and Consumer Protection|
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