Title: Analysis of toxicity effects from molecular to population level: Circadian oscillator case study
Authors: ZALDIVAR COMENGES Jose'
Citation: The Open Journal of Toxicology vol. 4 p. 1-12
Publisher: Bentham Science Publishers
Publication Year: 2010
JRC Publication N°: JRC54858
ISSN: 1874-3404
URI: http://www.bentham.org/open/totoxij/index.htm
http://publications.jrc.ec.europa.eu/repository/handle/JRC54858
DOI: 10.2174/1874340401004010001
Type: Articles in Journals
Abstract: To analyze how toxic effects propagate from molecular to population level, a simple model of a circadian oscillator has been coupled with a cyanobacteria growth model. It has been assumed that the circadian oscillator synchronizes with light-dark environmental conditions and toxicants affect this synchronization reducing the population growth. Then dose-response curves have been developed. The results evidence that to understand toxic effects we have to focus our study on the interactions that a certain compound may have with proteins, and/or DNA, since the result of these interactions will determine the final mode of action at macroscopic level. Therefore an intermediate step for assessing toxic effects has been proposed.
JRC Institute:Institute for Health and Consumer Protection

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