Title: Investigation of Para-sulfonatocalix[n]arenes [n = 6, 8] as Potential Chelates for 230U
Authors: MONTAVON GillesREPINC UrskaAPOSTOLIDIS ChristosBRUCHERTSEIFER FrankABBAS KamelMORGENSTERN Alfred
Citation: DALTON TRANSACTIONS vol. 39 p. 1366-1374
Publisher: ROYAL SOC CHEMISTRY
Publication Year: 2010
JRC N°: JRC54900
ISSN: 1477-9226
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC54900
DOI: 10.1039/b918426k
Type: Articles in Journals
Abstract: Literature reports of the efficacy of para-sulfonatocalix[6]- and calix[8]-arenes as U(VI) complexants indicated that they might be useful for in vivo chelation of the novel therapeutic alpha-emitter 230U. We have studied the complexation of U(VI) with para-sulfonatocalix[6]arene and para-sulfonatocalix[8]-arene by time resolved laser induced fluorescence spectroscopy and using competition methods with Chelex resin and 4-(2-pyridylazo)resorcinol in simplified and in biological media. New thermodynamic parameters describing the stability of U(VI)-para-sulfonatocalix[n]arene [n = 6, 8] complexes were obtained. Although the interactions are strong, the complexes do not exhibit sufficient stability to compete with carbonate ions and serum proteins for complexation of U(VI) under physiological
JRC Institute:Institute for Transuranium Elements

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