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|Title:||Investigation of Para-sulfonatocalix[n]arenes [n = 6, 8] as Potential Chelates for 230U|
|Authors:||MONTAVON Gilles; REPINC Urska; APOSTOLIDIS Christos; BRUCHERTSEIFER Frank; ABBAS Kamel; MORGENSTERN Alfred|
|Citation:||DALTON TRANSACTIONS vol. 39 p. 1366-1374|
|Publisher:||ROYAL SOC CHEMISTRY|
|Type:||Articles in periodicals and books|
|Abstract:||Literature reports of the efficacy of para-sulfonatocalix- and calix-arenes as U(VI) complexants indicated that they might be useful for in vivo chelation of the novel therapeutic alpha-emitter 230U. We have studied the complexation of U(VI) with para-sulfonatocalixarene and para-sulfonatocalix-arene by time resolved laser induced fluorescence spectroscopy and using competition methods with Chelex resin and 4-(2-pyridylazo)resorcinol in simplified and in biological media. New thermodynamic parameters describing the stability of U(VI)-para-sulfonatocalix[n]arene [n = 6, 8] complexes were obtained. Although the interactions are strong, the complexes do not exhibit sufficient stability to compete with carbonate ions and serum proteins for complexation of U(VI) under physiological|
|JRC Directorate:||Nuclear Safety and Security|
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