Title: Genotoxicity Assays Analysis for Carbon Nanotubes: Friends or Foes? Preliminary Results on Human Peripheral Peukocytes
Authors: COLOGNATO RenatoPONTI JessicaD'ERRICO Maria RitaMIGLORE LuciaROSSI Francois
Citation: International Journal of Environment and Health vol. 3 no. 3 p. 275-284
Publisher: Inderscience Publishers
Publication Year: 2009
JRC Publication N°: JRC55073
ISSN: 1743-4955
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC55073
DOI: 10.1504/IJENVH.2009.028593
Type: Articles in Journals
Abstract: The literature is full of information on the biological effects, both in vitro and in vivo, of Carbon Nanotubes (CNTs) and almost all the data published are in agreement on the toxicity related to physicochemical properties. The gap in the knowledge of the effects of CNTs on biological systems is instead evident when approaching the damage induced to DNA by CNTs. In fact, genotoxicity data is still missing. Is this due to a lack of interest in this field of research or it is triggered by the fact that standard procedures for genotoxicity assays are still to come for CNTs? Actually, the second question seems to be the more appropriate, but also for science, "in media stat virtus" remains valid. This brief review, including some preliminary results on human peripheral leukocytes, will try to highlight this problem as seen from the genotoxicological point of view.
JRC Institute:Institute for Health and Consumer Protection

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