Title: A biology-based dynamic approach for the reconciliation of acute and chronic toxicity tests: Application to Daphnia magna
Authors: ZALDIVAR COMENGES Jose'BARAIBAR FENTANES Joaquin
Publisher: Publications Office of the European Union
Publication Year: 2009
JRC N°: JRC55319
ISBN: 978-92-79-14550-6
ISSN: 1018-5593
Other Identifiers: EUR 24109 EN
OPOCE LB-NA-24109-EN-C
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC55319
DOI: 10.2788/49365
Type: EUR - Scientific and Technical Research Reports
Abstract: There is the need to integrate existing dose-response data in a coherent framework for extending their domain of applicability as well as their extrapolation potential. This integration would also reduce time and cost-consuming aspects of these tests and reduce animal usage. In this work, based on data extracted from literature, we have assessed the advantages that a dynamic biology- toxicant fate coupled model for Daphnia magna could provide when assessing toxicity data, in particular, the possibility to obtain from short-term (acute) toxicity test to long-term (chronic) toxicity values and viceversa; the possibility of toxicity data reconciliation from several sources and the inherent variability of Daphnia magna populations. Implicitly in this approach is the assumption that the mode of action of the toxicant does not change after prolonged exposure.
JRC Institute:Institute for Health and Consumer Protection

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