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|Title:||Cross-Sector Review of Drivers and Alternative Approaches for Acute Systemic Toxicity Testing|
|Authors:||SEIDLE Troy; ROBINSON Sally; HOLMES Tom; CRETON Stuart; PRIETO PERAITA Maria Del Pilar; SCHEEL Julia; CHLEBUS Magda|
|Citation:||TOXICOLOGICAL SCIENCES vol. 116 no. 2 p. 382-396|
|Publisher:||OXFORD UNIV PRESS|
|Type:||Articles in periodicals and books|
|Abstract:||Acute systemic toxicity studies are carried out in many sectors in which synthetic chemicals are manufactured or used, and are among the most criticized of all toxicology tests on both scientific and ethical grounds. A review of the drivers for acute toxicity testing within the pharmaceutical industry led to a paradigm shift whereby in vivo acute toxicity data are no longer routinely required in advance of human clinical trials. Based on this experience, the following review was undertaken to identify: 1) regulatory and scientific drivers for acute toxicity testing in other industrial sectors, 2) activities aimed at replacing, reducing, or refining the use of animals, and 3) recommendations for future work in this area.|
|JRC Institute:||Institute for Health and Consumer Protection|
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