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|Title:||Radioimmunotherapy of human bladder cancer in a nude mouse model comparing Bi-213-anti-EGFR-MAb and Th-226-anti-EGFR-MAb|
|Authors:||PFOST B.; MORGENSTERN Alfred; SEIDL C.; BRUCHERTSEIFER Frank; AUTENRIETH M.; APOSTOLIDIS Christos; ABBAS Kamel; SENEKOWITSCH-SCHMIDTKE R.|
|Citation:||JOURNAL OF NUCLEAR MEDICINE vol. 50 no. supplement 2 p. 36|
|Publisher:||SOC NUCLEAR MEDICINE INC|
|Type:||Articles in periodicals and books|
|Abstract:||Objectives: Transurethral resection of urothelial cancer still results in high recurrence rates. In new concepts for therapy of disseminated tumor cells -emitter immunoconjugates are applied. Therefore the aim of this study was to compare the therapeutic efficacy of Bi-213- and Th-226-anti-EGFR-MAb in an orthotopic EGFR-overexpressing bladder carcinoma model. Methods: 2x106 luciferase transfected EJ28 cancer cells were instilled into the bladders of female swiss nu/nu mice following urothelial electrocautery. 10 tumor-bearing mice each were intravesically instilled with 0.925 MBq of Bi-213-MAb or 0.37 MBq Th-226-MAb 1h, 7d and 14d after cell inoculation; controls received PBS. Tumor development and therapy response was imaged via bioluminescence imaging and survival observed up to 300d. Results: Mice of the control group reached a median survival of 41d. Bi-213-anti-EGFR therapy prolonged survival >300 d in 90%, 80% and 40% of animals treated 1h, 7d and 14d after cell instillation, respectively. Therapy with Th-226-MAb starting 10/2008 turned out to be as effective as Bi-213 therapy: 90% of animals of each group treated 1h, 7d and 14 d after cell inoculation are still alive without signs of toxicity. Conclusions: Both -emitter-anti-EGFR conjugates effectively eradicated disseminated tumor cells.Thus, therapy using Th-226-anti-EGFR might be a very promising supplement and/or alternative to Bi-213-anti-EGFR in treatment of urothelial cancer.|
|JRC Institute:||Institute for Transuranium Elements|
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