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|Title:||A Review of the Implementation of the Embryonic Stem Cell Test (EST)|
|Authors:||MARX STOELTING Philip; ADRIAENS Els; BREMER Susanne; PELLIZZER Cristian; SCHWARZ Michael; WEIMER Marc; GARTHOFF Bernwart; SPIELMANN Horst; VANPARYS Phillippe; VERWEI Miriam; ROGIERS Vera; REUTER Ulrike; PIERSMA Aldert; AHR Hans-Jurgen; GELBKE Heinz-Peter; SCHENK Barbara; SCHWENGBERG Silke; SEILER Andrea; STEEMANS Margino; STEDMAN Donald; VERICAT Joan Albert; VAN DE WATER Femke|
|Citation:||ATLA-ALTERNATIVES TO LABORATORY ANIMALS vol. 37 p. 313-328|
|Type:||Articles in periodicals and books|
|Abstract:||The EST has been developed as an in vitro screening test for evaluating the potential embryotoxic effects of substances, to allow their classification into three major classes: non-embryotoxic; weakly embryotoxic; and strongly embryotoxic). It is biologically based on the assumption that chemicals with an embryotoxic potential will block the spontaneous development of embryonic stem cells into beating cardiac muscle cells within the first 10 days of embryonic development . In 2002, the assay was endorsed by the ECVAM Scientific Advisory Committee (ESAC) as scientifically validated and ready to be considered for regulatory acceptance and application. the workshop has reviewed the post validated status of the EST so far.|
|JRC Institute:||Institute for Health and Consumer Protection|
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