Title: A Review of the Implementation of the Embryonic Stem Cell Test (EST)
Authors: MARX STOELTING PhilipADRIAENS ElsBREMER SusannePELLIZZER CristianSCHWARZ MichaelWEIMER MarcGARTHOFF BernwartSPIELMANN HorstVANPARYS PhillippeVERWEI MiriamROGIERS VeraREUTER UlrikePIERSMA AldertAHR Hans-JurgenGELBKE Heinz-PeterSCHENK BarbaraSCHWENGBERG SilkeSEILER AndreaSTEEMANS MarginoSTEDMAN DonaldVERICAT Joan AlbertVAN DE WATER Femke
Citation: ATLA-ALTERNATIVES TO LABORATORY ANIMALS vol. 37 p. 313-328
Publisher: FRAME
Publication Year: 2009
JRC N°: JRC55849
ISSN: 0261-1929
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC55849
Type: Articles in Journals
Abstract: The EST has been developed as an in vitro screening test for evaluating the potential embryotoxic effects of substances, to allow their classification into three major classes: non-embryotoxic; weakly embryotoxic; and strongly embryotoxic). It is biologically based on the assumption that chemicals with an embryotoxic potential will block the spontaneous development of embryonic stem cells into beating cardiac muscle cells within the first 10 days of embryonic development . In 2002, the assay was endorsed by the ECVAM Scientific Advisory Committee (ESAC) as scientifically validated and ready to be considered for regulatory acceptance and application. the workshop has reviewed the post validated status of the EST so far.
JRC Institute:Institute for Health and Consumer Protection

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