Title: Early Clinical Trial Concept for Boron Neutron Capture Therapy - A Critical Assessment of the EORTC Trial 11001
Authors: WITTIG AndreaCOLLETTE LaurenceMOSS RaymondSAUERWEIN Wolfgang
Citation: APPLIED RADIATION AND ISOTOPES vol. 67 no. 7-8S p. S59-S62
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Publication Year: 2009
JRC N°: JRC56052
ISSN: 0969-8043
URI: http://www.elsevier.com/locate/apradiso
http://publications.jrc.ec.europa.eu/repository/handle/JRC56052
DOI: 10.1016/j.apridiso.2009.03.012
Type: Articles in Journals
Abstract: BNCT causes selective damage to tumor cells by neutron capture reactions releasing high LET-particles where 10B-atoms are present. Neither the 10B-compound nor thermal neutrons alone have any therapeutic effect. Therefore, the development of BNCT to a treatment modality needs strategies, which differ from the standard phase I¿III clinical trials. An innovative trial design was developed including translational research and a phase I aspect. The trial investigates as surrogate endpoint BSH and BPA uptake in different tumor entities.
JRC Institute:Institute for Energy and Transport

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