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|Title:||Early Clinical Trial Concept for Boron Neutron Capture Therapy - A Critical Assessment of the EORTC Trial 11001|
|Authors:||WITTIG Andrea; COLLETTE Laurence; MOSS Raymond; SAUERWEIN Wolfgang|
|Citation:||APPLIED RADIATION AND ISOTOPES vol. 67 no. 7-8S p. S59-S62|
|Publisher:||PERGAMON-ELSEVIER SCIENCE LTD|
|Type:||Articles in periodicals and books|
|Abstract:||BNCT causes selective damage to tumor cells by neutron capture reactions releasing high LET-particles where 10B-atoms are present. Neither the 10B-compound nor thermal neutrons alone have any therapeutic effect. Therefore, the development of BNCT to a treatment modality needs strategies, which differ from the standard phase I¿III clinical trials. An innovative trial design was developed including translational research and a phase I aspect. The trial investigates as surrogate endpoint BSH and BPA uptake in different tumor entities.|
|JRC Institute:||Institute for Energy and Transport|
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