Title: Investigation of para-sulfonatocalix[n]arenes [n = 6, 8] as potential chelates for 230U†
Authors: MONTAVON GillesREPINC UrskaAPOSTOLIDIS ChristosBRUCHERTSEIFER FrankABBAS KamelMORGENSTERN Alfred
Citation: DALTON TRANSACTIONS vol. 39 no. 5 p. 1366–1374
Publisher: ROYAL SOC CHEMISTRY
Publication Year: 2010
JRC N°: JRC56357
ISSN: 1477-9226
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC56357
DOI: 10.1039/b918426k
Type: Articles in Journals
Abstract: The uranophiles calix[6]- and calix[8]arene have been reported to form strong complexes with U(VI) and may be suitable for in vivo chelation of the novel therapeutic alpha emitter 230U. We have studied the complexation of U(VI) with calix[6]arene and calix[8]arene by time resolved laser induced fluorescence spectroscopy and using competition methods with chelex resin and 4-(2-pyridylazo)resorcinol in simplified and in biological media. New thermodynamic parameters describing the stability of U(VI)-calix[n]arene (n = 6, 8) complexes were obtained. Although the interactions are strong, the complexes do not exhibit sufficient stability to compete with carbonate ions and serum proteins for complexation of U(VI) under physiological conditions.
JRC Institute:Institute for Health and Consumer Protection

Files in This Item:
There are no files associated with this item.


Items in repository are protected by copyright, with all rights reserved, unless otherwise indicated.