Title: Nano-TiO2 - feasibility and challenges for human health risk assessment based on open literature
Authors: CHRISTENSEN FransJOHNSTON Helinor JSTONE VickiAITKEN Robert JHANKIN StevePETERS SheonaASCHBERGER KARIN
Citation: NANOTOXICOLOGY vol. 5 no. 2 p. 110-124
Publisher: INFORMA HEALTHCARE
Publication Year: 2011
JRC N°: JRC56442
ISSN: 1743-5390
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC56442
DOI: 10.3109/17435390.2010.504899
Type: Articles in Journals
Abstract: This study aims at investigating feasibility and challenges associated with conducting a human health risk assessment for nanotitanium- dioxide (nano-TiO2) based on the open literature by following an approach similar to a classical regulatory risk assessment. Gaps in the available data set, both in relation to exposures and hazard, do not allow reaching any definite conclusions that could be used for regulatory decision-making. Results show that repeated inhalation in the workplace and possibly consumer inhalation may cause risks. Also short-term inhalation following spray applications may cause risks. Main future work should focus on generating occupational and consumer inhalation exposure data, as well as toxicity data on absorption following inhalation, repeated dermal contact, and contact with damaged skin. Also relevant seems further information on possible neurotoxicity and genotoxicity/carcinogenicity, as well as establishing a No Observed Adverse Effect Level (NOAEL) for acute inhalation of nano-TiO2.
JRC Institute:Institute for Health and Consumer Protection

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