Title: Production and quality control of hight specific activity NCA Re-186 by Cyclotron irradiation
Authors: GROPPI FlaviaBONARDI MauroMANENTI S.MARCHETTI M.GINI L.ABBAS KamelHOLZWARTH UweSIMONELLI Federica
Citation: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS vol. 52(S1) p. S253
Publisher: JOHN WILEY & SONS LTD
Publication Year: 2009
JRC Publication N°: JRC56478
ISSN: 0362-4803
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC56478
Type: Contributions to Conferences
Abstract: The applications of the radionuclides play a fundamental role in life sciences and in particular nowadays is becoming an indispensable branch of medical science with the radionuclides and labeled compounds production for medical applications. The Re-186g is a negatron-gamma emitter presently used in metabolic radiotherapy with optimal perspectives to be used in radioimmunotherapy too, thanks to its suitable nuclear properties: t1/2=90.64 h, main E¿=137 keV, Eß,max=1 071 keV, energy range suitable to treat cancers with dimensions from few mm to a few cm. The possibility to use this radionuclide for therapeutic purposes is linked to the possibility to increase its specific activity AS, substituting the common (n,¿) reaction on Re-185 with the (p,n) or (d,2n) cyclotron production on W-186 targets, followed by a selective radiochemical separation of the product in no-carrier-added form from both W target and Ta co-produced radionuclides.
JRC Institute:Institute for Health and Consumer Protection

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