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|Title:||Production and quality control of hight specific activity NCA Re-186 by Cyclotron irradiation|
|Authors:||GROPPI Flavia; BONARDI Mauro; MANENTI S.; MARCHETTI M.; GINI L.; ABBAS Kamel; HOLZWARTH Uwe; SIMONELLI Federica|
|Citation:||JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS vol. 52(S1) p. S253|
|Publisher:||JOHN WILEY & SONS LTD|
|Type:||Articles in periodicals and books|
|Abstract:||The applications of the radionuclides play a fundamental role in life sciences and in particular nowadays is becoming an indispensable branch of medical science with the radionuclides and labeled compounds production for medical applications. The Re-186g is a negatron-gamma emitter presently used in metabolic radiotherapy with optimal perspectives to be used in radioimmunotherapy too, thanks to its suitable nuclear properties: t1/2=90.64 h, main E¿=137 keV, Eß,max=1 071 keV, energy range suitable to treat cancers with dimensions from few mm to a few cm. The possibility to use this radionuclide for therapeutic purposes is linked to the possibility to increase its specific activity AS, substituting the common (n,¿) reaction on Re-185 with the (p,n) or (d,2n) cyclotron production on W-186 targets, followed by a selective radiochemical separation of the product in no-carrier-added form from both W target and Ta co-produced radionuclides.|
|JRC Institute:||Institute for Health and Consumer Protection|
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