Title: In vitro and in vivo comparison of 226Th and 213Bi-labelled radioconjugates for target alpha therapy
Authors: BRUCHERTSEIFER FrankMORGENSTERN AlfredFRIESEN CLAUDIAROSCHER MAREIKEMILTNER E.PFOST B.SENEKOWITSCH-SCHMIDTKE R.ABBAS KamelAPOSTOLIDIS Christos
Citation: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING vol. 36 (Supplement 2) p. S279
Publisher: SPRINGER
Publication Year: 2009
JRC N°: JRC56516
ISSN: 1619-7070
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC56516
Type: Contributions to Conferences
Abstract: The novel short-lived alpha emitter 226Th (t1/2 = 31 min) decays via a rapid cascade of four alpha particles with a cumulative energy of 27.7 MeV. The single alpha emitter 213Bi (t1/2 = 31 min) emits one alpha particle of 8.4 MeV per decay. We compare the cytotoxicity of 226Th- vs. 213Bi-labelled radioconjugates towards sensitive and chemo- and radioresistant myeloid leukemia cells in vitro and in a bladder carcinoma model in vivo.
JRC Institute:Institute for Health and Consumer Protection

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