Title: Standardization of Protein Biomarker Measurements: Is It Feasible?
Authors: SCHIMMEL HeinzZEGERS IngridEMONS Hendrik
Citation: SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION vol. 70 no. Suppl. 242 p. 27-33
Publisher: TAYLOR & FRANCIS AS
Publication Year: 2010
JRC N°: JRC56556
ISSN: 0036-5513
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC56556
DOI: 10.3109/00365513.2010.493362
Type: Articles in Journals
Abstract: The standardisation of measurements of protein biomarkers, which are potentially heterogeneous in terms of fragmentation, modification, substitution, primary, secondary, tertiary and quaternary structure, is a demanding task. However, they are a prime target for standardisation efforts due to the importance of protein biomarkers in diagnostics and health care and the typically observed significant discrepancies in measurement results obtained with non-standardized platforms. Based on the experience gathered during successfully completed projects for the production of reference materials, pragmatic approaches are described how standardisation could become feasible despite the fuzziness of the target analytes.
JRC Institute:Institute for Reference Materials and Measurements

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