Title: Radioimmunotherapy is More Effective than Antifungal Treatment in Experimental Cryptococcal Infection
Authors: BRYAN R. A.JIANG Z.HOWELL RobertaMORGENSTERN AlfredBRUCHERTSEIFER FrankCASADEVALL A.DADACHOVA E.
Citation: JOURNAL OF INFECTIOUS DISEASES vol. 202 no. 4 p. 633-637
Publisher: UNIV CHICAGO PRESS
Publication Year: 2010
JRC N°: JRC57422
ISSN: 0022-1899
URI: http://www.journals.uchicago.edu/toc/jid/current
http://publications.jrc.ec.europa.eu/repository/handle/JRC57422
DOI: 10.1086/654813
Type: Articles in Journals
Abstract: Radioimmunotherapy (RIT) prolongs survival of mice infected with Cryptococcus neoformans (CN). To compare the efficacy of RIT and amphotericin B, we infected AJCr mice IV with either nonmelanized or melanized CN cells. Infected mice were either left untreated, treated 24 hours post infection with 213Bi-18B7 antibody or amphotericin or both. Melanization before infection did not increase resistance of CN to RIT in vivo. 213Bi-18B7 treatment almost completely eliminated lung and brain CFUs while amphotericin did not decrease CFUs. We conclude that RIT is more effective than amphotericin against systemic infection with CN.
JRC Institute:Institute for Transuranium Elements

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