Title: Protein-Nanoparticle Interaction: Identification of the Ubiquitin-Gold Nanoparticle Interaction Site
Authors: CALZOLAI LUIGIFRANCHINI FabioGILLILAND DouglasROSSI Francois
Citation: NANO LETTERS vol. 10 no. 8 p. 3101-3105
Publisher: AMER CHEMICAL SOC
Publication Year: 2010
JRC N°: JRC58386
ISSN: 1530-6984
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC58386
DOI: 10.1021/nl101746v
Type: Articles in Journals
Abstract: We demonstrated that it is possible to identify the protein-nanoparticle interaction site at amino acid scale in solution. Using NMR, chemical shift perturbation analysis, and dynamic light scattering we have identified a specific domain of human ubiquitin that interacts with gold nanoparticles. This method allows a detailed structural analysis of proteins absorbed onto surfaces of nanoparticles in physiological conditions and it will provide much needed experimental data for better modelling and prediction of protein-nanopartide interactions.
JRC Institute:Institute for Health and Consumer Protection

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