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|Title:||Protein-Nanoparticle Interaction: Identification of the Ubiquitin-Gold Nanoparticle Interaction Site|
|Authors:||CALZOLAI LUIGI; FRANCHINI Fabio; GILLILAND Douglas; ROSSI Francois|
|Citation:||NANO LETTERS vol. 10 no. 8 p. 3101-3105|
|Publisher:||AMER CHEMICAL SOC|
|Type:||Articles in periodicals and books|
|Abstract:||We demonstrated that it is possible to identify the protein-nanoparticle interaction site at amino acid scale in solution. Using NMR, chemical shift perturbation analysis, and dynamic light scattering we have identified a specific domain of human ubiquitin that interacts with gold nanoparticles. This method allows a detailed structural analysis of proteins absorbed onto surfaces of nanoparticles in physiological conditions and it will provide much needed experimental data for better modelling and prediction of protein-nanopartide interactions.|
|JRC Directorate:||Institute for Health and Consumer Protection Historical Collection|
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