Title: Standardizing Plasma Protein Measurements Worldwide: A Challenging Enterprise
Authors: MERLINI GiampaoloBLIRUP-JENSEN SorenJOHNSON M.SHELDON JoannaZEGERS Ingrid
Citation: CLINICAL CHEMISTRY AND LABORATORY MEDICINE vol. 48 no. 11 p. 1567-1575
Publisher: WALTER DE GRUYTER & CO
Publication Year: 2010
JRC N°: JRC58478
ISSN: 1434-6621
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC58478
DOI: 10.1515/CCLM.2010.314
Type: Articles in Journals
Abstract: The need for harmonizing laboratory results is particularly intense in the field of quantitative protein assays in consideration of the clinical impact of specific protein measurements and their relevance in monitoring disease. We report the efforts made by the Committee on Plasma Proteins of the IFCC Scientific Division to achieve worldwide comparability in plasma protein results. We focus on the production of reference materials and the methods applied throughout their production process. Particularly, the recent characterization of ERM-DA470k/IFCC and ERM-DA472/IFCC has demonstrated that it is possible to reproduce the earlier established procedures and thereby maintain standardization. Plasma protein reference materials have had a substantial impact in improving the harmonization of patient protein results that should translate into better patient care.
JRC Institute:Institute for Reference Materials and Measurements

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