Title: An external cyclotron target system for nanoparticle sample activation
Authors: ABBAS KamelGIBSON PeterHORSTMANN WijbeHOLZWARTH UweARROJA FernandoSIMONELLI FedericaKOZEMPEL JANBULGHERONI ANTONIOCYDZIK Izabela
Citation: CHEMICKE LISTY vol. 104 no. 14 (Special Issue) p. s203
Publisher: CHEMICKE LISTY
Publication Year: 2010
JRC Publication N°: JRC59054
ISSN: 0009-2770
URI: http://www.chemicke-listy.cz/docs/full/2010_14_s198-s205.pdf
http://publications.jrc.ec.europa.eu/repository/handle/JRC59054
Type: Contributions to Conferences
Abstract: The need for toxicity assessment of industrially relevant nanoparticle materials implies that in vitro and in vivo biokinetics studies are required. Radiolabelled nanoparticles are an excellent candidate for such biodistribution measurements and are also of high interest for particle tracing and fate studies in other areas. We describe here an external target system for direct activation of dry nanoparticle samples, with He or water cooling, which is attached to an external beamline of the JRC Scanditronix MC-40 cyclotron at Ispra, Italy. A specially designed capsule is used to hold several tens of mg of nanoparticle powder material to be irradiated. The target system design and cooling system is described, and considerations regarding energy deposition, yield, heat transfer, radiation damage and radiotracer recoil are discussed.
JRC Institute:Institute for Health and Consumer Protection

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