Title: Reference Materials for Measuring the Size of Nanoparticles
Citation: TRAC-TRENDS IN ANALYTICAL CHEMISTRY vol. 30 no. 1 p. 18-27
Publication Year: 2011
JRC N°: JRC59424
ISSN: 0165-9936
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC59424
DOI: 10.1016/j.trac.2010.09.005
Type: Articles in periodicals and books
Abstract: This article discusses the requirements for reference materials (RMs) for measuring the size of nanoparticles (NPs). Such RMs can be used for instrument calibration, statistical quality control or interlaboratory comparisons. They can come in the form of suspensions, powders or matrix-embedded materials [i.e. NPs integrated in a natural matrix (e.g., food, soil, or sludge)]. At present, uncertainty about the most suitable form of material, the most relevant measurands and the most useful metrological-traceability statement inhibits the production of NP RMs. In addition, the lack of validated methods and qualified laboratories to produce NP RMs present formidable challenges. Metal, inorganic and organic NPs are available, but most of them are intended to be laboratory chemicals. With the exception of latex materials, certified RMs are not available, although some metrology institutes have started to develop such materials for colloidal gold and silica particles.
JRC Directorate:Health, Consumers and Reference Materials

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