Please use this identifier to cite or link to this item:
|Title:||Dual MRI-SPECT agent for pH-mapping|
|Authors:||GIANOLIO Eliana; MACIOCCO Luca; IMPERIO Daniela; GIOVENZANA Giovanni; SIMONELLI Federica; ABBAS Kamel; BISI Gianni; AIME Silvio|
|Citation:||CHEMCOMM vol. 47 no. 5 p. 1539-1541|
|Publisher:||ROYAL SOC CHEMISTRY|
|Type:||Articles in Journals|
|Abstract:||Up to now MR images report about the body anatomy; the use of currently available contrast agents allows to add relevant physiological information related to perfusion, flow, vascular permeability, etc. The next generation of MR agents will allow to acquire images that represent maps of the physico-chemical/biological parameters of interest. As representative example of the above depicted approach, we looked at pH-mapping as this parameter is known to change in the presence of several important diseases like tumor, stroke, infections. One of the crucial points to be considered designing a ¿smart¿ MR- contrast agent, is the need of knowing its local concentration in order to unambiglusly assign the observed relaxation rate variations to changes in the parameter of interest. In this work we overccame this drawback through a dual MRI/SPECT probe where the SPECT active moiety acts as a reporter of the concentration of the MRI responsive one. By properly designing the structure of the L ligand, the proof of concept acquired with this dual MRI/SPECT pH-responsive agent can be extended to different applications, for instance as responsive to enzymatic activity or metabolites concentration.|
|JRC Institute:||Institute for Health and Consumer Protection|
Files in This Item:
There are no files associated with this item.
Items in repository are protected by copyright, with all rights reserved, unless otherwise indicated.