Title: Synthesis, Structural, DFT, and Cytotoxicity Studies of CuII and NiII Complexes with 3-Aminopyrazole Derivatives
Authors: HOLLÓ BertaLEOVAC Vukadin M.JOVANOVIC Ljiljana S.DIVJAKOVIC VladimirMÉSZÁROS SZÉCSÉNYI KatalinBOMBICZ PetraKOVACS ATTILABOGDANOVIC GordanaKOJIC VesnaJOKSOVIC Milan D.
Citation: AUSTRALIAN JOURNAL OF CHEMISTRY no. 63 p. 1557 - 1564
Publisher: CSIRO PUBLISHING
Publication Year: 2010
JRC Publication N°: JRC62362
ISSN: 0004-9425
URI: http://www.publish.csiro.au/paper/CH10210.htm
http://publications.jrc.ec.europa.eu/repository/handle/JRC62362
DOI: 10.1071/CH10210
Type: Articles in Journals
Abstract: Template synthesis of N,N 0-bis(4-acetyl-5-methylpyrazole-3-yl)formamidine (ampf) was performed starting from 4-acetyl-3- amino-5-methylpyrazole (aamp) andCH(OC2H5)3 in methanol in the presence of CuCl2, Cu(NO3)2, orNi(NO3)2. The ligand was isolated in coordinated form as [Cu(ampf )Cl2], [Cu(ampf )(MeOH)(NO3)2]MeOH, and [Ni(ampf )(MeOH)2(NO3)]NO3 correspondingly. The compounds were characterized by elemental analysis, Fourier-transform IRand electronic spectroscopy, thermal analysis, single-crystal X-ray diffraction, and quantumchemical (density functional theory) calculations. The density functional theory calculations provided information on the metal¿ligand interactions in the complexes and assisted the assignment of the FT-IR spectra. The antiproliferative activity of the complexes and the ligand precursor, aamp, was tested against human myelogenous leukaemia K562, colon adenocarcinoma HT29, and cervix carcinoma HeLa.
JRC Institute:Institute for Transuranium Elements

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