Title: Treatment of early and established Cryptococcus neoformans infection with radiolabeled antibodies in immunocompetent mice
Authors: JIANG Z.BRYAN R. A.MORGENSTERN AlfredBRUCHERTSEIFER FrankCasadevall ArturoDADACHOVA E.
Citation: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY vol. 56 no. 1 p. 552-554
Publisher: AMER SOC MICROBIOLOGY
Publication Year: 2012
JRC Publication N°: JRC65534
ISSN: 0066-4804
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC65534
DOI: 10.1128/AAC.00473-11
Type: Articles in Journals
Abstract: We investigated the utility of radioimmunotherapy (RIT) in early and established cryptococcal infection in immunocompetent mice. RIT with 213Bi-18B7 antibody completely eliminated fungus from mouse lungs and brains for early infection, while 188Re- 18B7 significantly reduced CFU in the lungs or both lungs and brains during early and established infection, respectively. The results point to the independence of RIT of the immune status of the host, which is encouraging for translation of this strategy into the clinic.
JRC Institute:Institute for Transuranium Elements

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