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|Title:||Weak estrogenic transcriptional activities of Bisphenol A and Bisphenol S|
|Authors:||GRIGNARD ELISE; BREMER Susanne; LAPENNA SILVIA|
|Citation:||TOXICOLOGY IN VITRO vol. 26 no. 5 p. 727–731|
|Publisher:||PERGAMON-ELSEVIER SCIENCE LTD|
|Type:||Articles in Journals|
|Abstract:||In 2011, the European Commission has restricted the use of Bisphenol A in plastic infant feeding bottles. In a response to this restriction, Bisphenol S is now often used as a component of plastic substitutes for the production of babybottles. One of the major concerns leading to the restriction of Bisphenol A was its weak estrogenic activity. By using two highly standardised transactivation assays, we could demonstrate that the estrogenic activity of Bisphenol A and Bisphenol S is of a comparable potency. Furthermore, some insights about the structure-activity relationships of these two chemicals and their metabolites could be gained from in silico predictions of their relative estrogen receptor-binding affinities and their liver phase-I biotransformation.|
|JRC Institute:||Institute for Health and Consumer Protection|
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