Title: Weak estrogenic transcriptional activities of Bisphenol A and Bisphenol S
Authors: GRIGNARD ELISEBREMER SusanneLAPENNA SILVIA
Citation: TOXICOLOGY IN VITRO vol. 26 no. 5 p. 727–731
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Publication Year: 2012
JRC Publication N°: JRC65672
ISSN: 0887-2333
URI: http://www.sciencedirect.com/science/article/pii/S0887233312000847
http://publications.jrc.ec.europa.eu/repository/handle/JRC65672
DOI: 10.1016/j.tiv.2012.03.013
Type: Articles in Journals
Abstract: In 2011, the European Commission has restricted the use of Bisphenol A in plastic infant feeding bottles. In a response to this restriction, Bisphenol S is now often used as a component of plastic substitutes for the production of babybottles. One of the major concerns leading to the restriction of Bisphenol A was its weak estrogenic activity. By using two highly standardised transactivation assays, we could demonstrate that the estrogenic activity of Bisphenol A and Bisphenol S is of a comparable potency. Furthermore, some insights about the structure-activity relationships of these two chemicals and their metabolites could be gained from in silico predictions of their relative estrogen receptor-binding affinities and their liver phase-I biotransformation.
JRC Institute:Institute for Health and Consumer Protection

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