Title: Point: Put simply, standardization of Cardiac Troponin I is complicated
Authors: CHRISTENSON RobertBUNK DavidSCHIMMEL HeinzTATE Jilian
Citation: CLINICAL CHEMISTRY vol. 58 no. 1 p. 165-168
Publisher: AMER ASSOC CLINICAL CHEMISTRY
Publication Year: 2012
JRC N°: JRC66171
ISSN: 0009-9147
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC66171
DOI: 10.1373/clinchem.2011.166140
Type: Articles in Journals
Abstract: The manuscript presents the point of view in favour of standardisation in a point-counterpoint article series in Clinical Chemistry. The article stresses the importance of reference measurement procedures and defining appropriately the analytical target taking the particular biochemistry of troponin I, a very important hart infarction marker, into consideration. The biochemical challenges in troponin I standardisation and the concept followed by the IFCC working group aiming at the establishment of a reference system are described. The conclusion is drawn that standardisation of troponin I is complicated but possible and worth the effort seen the positive impact of a successful standardisation on clinical decision making and patient care.
JRC Institute:Institute for Reference Materials and Measurements

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