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|Title:||Lipophilic Silver Nanoparticles and Their Polymeric Entrapment into Targeted-PEG-Based Micelles for the Treatment of Glioblastoma|
|Authors:||LOCATELLI Erica; BROGGI Francesca; PONTI Jessica; MARMORATO Patrick; FRANCHINI Fabio; LENA Stefano; COMES FRANCHINI Mauro|
|Citation:||ADVANCED MATERIALS vol. 1 no. 3 p. 342-347|
|Type:||Articles in Journals|
|Abstract:||A simple method for the synthesis of lipophilic Ag NPs have been developed. The coated Ag NPs have been entrapped into a FDA-approved and targetable PEG-based polymeric nanoparticles, and this nanocarrier has been conjugated with the peptide chlorotoxin. Uptake experiments have shown a cell-specific recognition of the Ag-1-PNPs-Cltx on U87MG cell lines in comparison to Balb/3T3. The uptake of Ag into the cells was quantified and an interesting cytotoxic effect (IC50 = 45 μM) has been found on glioblastoma cell lines.|
|JRC Institute:||Institute for Health and Consumer Protection|
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