Title: Lipophilic Silver Nanoparticles and Their Polymeric Entrapment into Targeted-PEG-Based Micelles for the Treatment of Glioblastoma
Authors: LOCATELLI EricaBROGGI FrancescaPONTI JessicaMARMORATO PatrickFRANCHINI FabioLENA StefanoCOMES FRANCHINI Mauro
Citation: ADVANCED MATERIALS vol. 1 no. 3 p. 342-347
Publisher: WILEY-BLACKWELL
Publication Year: 2012
JRC N°: JRC67965
ISSN: 0935-9648
URI: http://onlinelibrary.wiley.com/doi/10.1002/adhm.201100047/abstract
http://publications.jrc.ec.europa.eu/repository/handle/JRC67965
DOI: 10.1002/adhm.201100047
Type: Articles in Journals
Abstract: A simple method for the synthesis of lipophilic Ag NPs have been developed. The coated Ag NPs have been entrapped into a FDA-approved and targetable PEG-based polymeric nanoparticles, and this nanocarrier has been conjugated with the peptide chlorotoxin. Uptake experiments have shown a cell-specific recognition of the Ag-1-PNPs-Cltx on U87MG cell lines in comparison to Balb/3T3. The uptake of Ag into the cells was quantified and an interesting cytotoxic effect (IC50 = 45 μM) has been found on glioblastoma cell lines.
JRC Institute:Institute for Health and Consumer Protection

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