Title: Characterisation of a Setup for Mixed Beam Exposures of Cells to 241Am Alpha Particles and X-Rays
Authors: STAAF ElinaBREHWENS KarlHAGHDOOST SiamakPACHNEROVA-BRABCOVA KaterinaCZUB JoannaBRAZIEWICZ JanuszNIEVAART SanderWOJCIK Andrzej
Citation: RADIATION PROTECTION DOSIMETRY vol. 151 no. 3 p. 570-579
Publisher: OXFORD UNIV PRESS
Publication Year: 2012
JRC N°: JRC70086
ISSN: 0144-8420
URI: http://rpd.oxfordjournals.org/content/151/3/570.full
http://publications.jrc.ec.europa.eu/repository/handle/JRC70086
DOI: 10.1093/rpd/ncs024
Type: Articles in Journals
Abstract: Exposure of humans to mixed fields of high and low linear energy transfer (LET) radiation occurs in many situations, for example in urban areas with high levels of indoor radon as well as background gamma radiation, during airplane flights or certain forms of radiation therapy. From the perspective of health risk associated with exposure to mixed fields it is important to understand the interactions between the different radiation types. In most cellular investigations on mixed beams the two types of irradiations have been applied sequentially. Simultaneous irradiation is the desirable scenario but requires a dedicated irradiation facility. We have constructed such a facility where cells can be simultaneously exposed to 241 Am alpha particles and 190 kV X-rays at 37oC. In this technical report we present the technical details and the dosimetry of the setup, as well as validating the performance of the setup for clonogenic survival in AA8 Chinese hamster ovary cells. No significant synergistic effect was observed. The relative biological effectiveness (RBE) of the alpha particles was 2.56 for 37% and 1.90 for 10% clonogenic survival.
JRC Institute:Institute for Energy and Transport

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