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|Title:||Orthotopic administration of 213Bi-Bevacizumab inhibits progression of PC3 xenografts in the prostate|
|Authors:||RIZVI S.m.a.; ALLEN B.j.; LEE C.s.; BRUCHERTSEIFER Frank; MORGENSTERN Alfred; APOSTOLIDIS Christos; CLARKE R.a.|
|Citation:||IMMUNOTHERAPY vol. 4 no. 5 p. 1-6|
|Publisher:||FUTURE MEDICINE LTD|
|Type:||Articles in periodicals and books|
|Abstract:||Tumour growth requires development of new blood vessels – a process known as angiogenesis. The anti-angiogenic monoclonal antibody Bevacizumab (BZ), which targets vascular endothelial growth factor (VEGF), is now part of the standard treatment for advanced colorectal cancer. Castrate resistant prostate cancers also express VEGF but are only marginally responsive to BZ alone or in combination with chemotherapy. Targeted alpha-radioimmunotherapy (TAT) is an emerging technology that can safely enhance immunotherapy for improved cancer control. TAT targeting can be further enhanced through orthotopic delivery. In this preliminary study we investigate orthotopic TAT for the control of early-stage prostate cancer PC3 xenografts using alpha radio-labelled BZ (213Bi-BZ). Results indicate that orthotopic administration of 213Bi- BZ greatly improves the early control of organ confined prostate cancer compared to BZ alone (P<0.01).|
|JRC Directorate:||Nuclear Safety and Security|
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