Title: Branched Amphiphilic Peptide Capsules: Cellular Uptake and Retention of Encapsulated Solutes
Authors: SUKTHANKAR PinakinAVILA AdrianaWHITAKER SusanIWAMOTO TakeoMORGENSTERN AlfredAPOSTOLIDIS ChristosLIU KeHANZLIK RobertDADACHOVA E.TOMICH John
Citation: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES vol. 1838 no. 9 p. 2296-2305
Publisher: ELSEVIER SCIENCE BV
Publication Year: 2014
JRC N°: JRC88816
ISSN: 0005-2736
URI: http://www.sciencedirect.com/science/article/pii/S0005273614000698
http://publications.jrc.ec.europa.eu/repository/handle/JRC88816
DOI: 10.1016/j.bbamem.2014.02.005
Type: Articles in periodicals and books
Abstract: Branched Amphiphilic Peptide Capsules (BAPCs) are peptide nano-spheres comprised of equimolar proportions of two branched peptide sequences bis(FLIVI)-K-KKKK and bis(FLIVIGSII)-K-KKKK that self-assemble to form bilayer delimited capsules. In two recent publications we described the lipid analogous characteristics of our BAPCs and examined their initial assembly, mode of fusion, solute encapsulation, resizing and delineated their capability to be maintained at a specific size by storing them at 4°C. In this report we describe the stability, size limitations of encapsulation, cellular localization, retention and, bio-distribution of the BAPCs in vivo. The ability of our constructs to retain alpha particle emitting radionuclides without any apparent leakage and their persistence in the peri-nuclear region of the cell for extended periods of time, coupled with their ease of preparation and potential tune-ability, makes them attractive as biocompatible carriers for targeted cancer therapy using particle emitting radioisotopes.
JRC Directorate:Nuclear Safety and Security

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