Title: t4 Workshop Report: Integrated Testing Strategies (ITS) for Safety Assessment
Authors: ROVIDA CostanzaALEPEE NathalieAPI Anne MarieBASKETTER DavidBOIS Frederic YvesCALONI FrancescaCORSINI EmanuelaDANESHIAN MardasESKES ChantraEZENDAM JanineFUCHS HorstHAYDEN PatrickHEGELE-HARTUNG ChristaHOFFMANN SebastianHUBESCH BrunoJACOBS MiriamJAWORSKA JoannaKLEENSANG AndreKLEINSTREUER NicoleLALKO JonLANDSIEDEL RobertLEBREUX FredericLUECHTEFELD ThomasLOCATELLI MonicaMEHLING AnnetteNATSCH AndreasPITCHFORD Jonathan W.PRATER DonaldPRIETO PERAITA Maria Del PilarSCHEPKY AndreasSCUURMANN GerritSMIRNOVA LenaTOOLE ColleenVAN VLIET ErwinWEISENSEE DirkHartung T.
Citation: ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION vol. 32 no. 1 p. 25-40
Publisher: SPEKTRUM AKADEMISCHER VERLAG-SPRINGER-VERLAG GMBH
Publication Year: 2015
JRC N°: JRC91149
ISSN: 1868-596X
URI: http://www.altex.ch/All-issues/Issue.50.html?iid=152&aid=3
http://publications.jrc.ec.europa.eu/repository/handle/JRC91149
DOI: 10.14573/altex.1411011
Type: Articles in periodicals and books
Abstract: Integrated testing strategies (ITS), as opposed to single definitive tests or fixed batteries of tests, are expected to efficiently combine different information sources in a quantifiable fashion to satisfy an information need, in this case for regulatory safety assessments. With increasing awareness of the limitations of each individual tool and the development of highly targeted tests and predictions, the need for combining pieces of evidence increases. The discussions that took place during this workshop, which brought together a group of experts coming from different related areas, illustrate the current state of the art of ITS, as well as promising developments and identifiable challenges. The case of skin sensitization was taken as an example to understand how possible ITS can be constructed, optimized and validated. This will require embracing and developing new concepts such as adverse outcome pathways (AOP), advanced statistical learning algorithms and machine learning, mechanistic validation and “Good ITS Practices”.
JRC Directorate:Institute for Health and Consumer Protection Historical Collection

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