Title: diXa: a Data Infrastructure for Chemical Safety Assessment
Authors: HENDRICKX Diana M.AERTS Hugo J.w.l.CAIMENT FlorianCLARK DominicEBBELS TimothyEVELO ChrisGMUENDER HansHEBELS Dennie G.a.j.HERWIG RalfHESCHELER JuergenJENNEN Danyel G.j.JETTEN Marlon J.a.KANTERAKIS StathisKEUN Hector C.MATSER VeraOVERINGTON John P.PILICHEVA EkaterinaSARKANS UgisSEGURA-LEPE Marcelo P.SOTIRIADOU IsaiaWITTENBERGER TimoWITTWEHR ClemensZANZI ANTONELLAKLEINJANS Jos
Citation: BIOINFORMATICS vol. 31 no. 9 p. 1505-1507
Publisher: OXFORD UNIV PRESS
Publication Year: 2014
JRC N°: JRC93559
ISSN: 1367-4803
URI: http://bioinformatics.oxfordjournals.org/content/early/2014/12/11/bioinformatics.btu827
http://publications.jrc.ec.europa.eu/repository/handle/JRC93559
DOI: 10.1093/bioinformatics/btu827
Type: Articles in periodicals and books
Abstract: Motivation: The field of toxicogenomics (the application of ‘-omics’ technologies to risk assessment of compound toxicities) has expanded in the last decade, partly driven by new legislation, aimed at reducing animal testing in chemical risk assessment but mainly as a result of a paradigm change in toxicology towards the use and integration of genome wide data. Many research groups worldwide have generated large amounts of such toxicogenomics data. However, there is no centralized repository for archiving and making these data and associated tools for their analysis easily available. Results: The Data Infrastructure for Chemical Safety Assessment (diXa) is a robust and sustainable infrastructure storing toxicogenomics data. A central data warehouse is connected to a portal with links to chemical information and molecular and phenotype data. diXa is publicly available through a user-friendly web interface. New data can be readily deposited into diXa using guidelines and templates available online. Analysis descriptions and tools for interrogating the data are available via the diXa portal.
JRC Directorate:Institute for Health and Consumer Protection Historical Collection

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