Title: Radioimmunothérapie alpha Principes et intérêts en immunité antitumorale
Authors: MENAGER JGORIN JFICHOU NolwennGOUARD S.MORGENSTERN AlfredBRUCHERTSEIFER FrankDAVODEAU FKRAEBER BODÉRÉ FCHEREL M.GASCHET JGUILLOUX Yannick
Publisher: EDP Sciences
Publication Year: 2016
JRC N°: JRC97048
ISSN: 0767-0974
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC97048
DOI: 10.1051/medsci/20163204014
Type: Articles in periodicals and books
Abstract: Alpha-radioimmunotherapy (α-RIT) is a targeted anti-tumor therapy using usually a monoclonal antibody specific for a tumor antigen that is coupled to an α-particle emitter. α-emitters represent an ideal tool to eradicate disseminated tumors or metastasis. Recent data demonstrate that ionizing radiation in addition to its direct cytotoxic ability can also induce an efficient anti-tumor immunity. This suggests that biologic effects on irradiated tissues could be used to potentiate immunotherapy efficacy and open door to development of new therapies combining α-RIT and different types of immunotherapy.
JRC Directorate:Nuclear Safety and Security

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