Title: t4 Workshop Report: Non-Animal Models of Epithelial Barriers (Skin, Intestine and Lung) in Research, Industrial Applications and Regulatory Toxicology
Authors: GORDON SarahDANESHIAN MardasBOUWSTRA JokeCALONI FrancescaCONSTANT SamuelDAVIES Donna E.DANDEKAR GudrunGUZMAN Carlos A.FABIAN EricHALTNER-UKOMADU EleonoreHartung T.HASIWA MarinaHAYDEN PatrickKANDAROVA HelenaKHARE SangeetaKRUG Harald F.KNEUER CarstenLEIST MarcelGUOPING LianMARX UweMETZGER MarcoOTT KatharinaPRIETO PERAITA Maria Del PilarROBERTS Michael S.ROGGEN ErwinTRALAU TewesVAN DEN BRAAK ClaudiaWALLES HeikeLEHR Claus-Michael
Citation: ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION vol. 32 no. 4 p. 327-378
Publisher: SPEKTRUM AKADEMISCHER VERLAG-SPRINGER-VERLAG GMBH
Publication Year: 2015
JRC N°: JRC97484
ISSN: 1868-596X
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC97484
DOI: 10.14573/altex.1510051
Type: Articles in periodicals and books
Abstract: Models of the outer epithelia of the human body – namely the skin, the intestine and the lung – have found valid applications in both research and industrial settings as attractive alternatives to animal testing. A variety of approaches to model these barriers are currently employed in such fields, ranging from the utilization of ex vivo tissue to reconstructed in vitro models, and further to chip-based technologies, synthetic membrane systems and, of increasing current interest, in silico modeling approaches. An international group of experts in the field of epithelial barriers was convened from academia, industry and regulatory bodies to present both the current state of the art of non-animal models of the skin, intestinal and pulmonary barriers in their various fields of application, and to discuss research-based, industry-driven and regulatory-relevant future directions for both the development of new models and the refinement of existing test methods. Issues of model relevance and preference, validation and standardization, acceptance, and the need for simplicity versus complexity were focal themes of the discussions. The outcomes of workshop presentations and discussions, in relation to both current status and future directions in the utilization and development of epithelial barrier models, are presented by the attending experts in the current report.
JRC Directorate:Institute for Health and Consumer Protection Historical Collection

Files in This Item:
There are no files associated with this item.


Items in repository are protected by copyright, with all rights reserved, unless otherwise indicated.