Title: Gold nanoparticles increases UV and thermal stability of human serum albumin
Authors: CAPOMACCIO ROBIN BRUNOOSORIO InesOJEA JIMENEZ ISAACCECCONE GiacomoCOLPO PascalGILLILAND DouglasHUSSAIN RohanahSILIGARDI GiulianoROSSI FrancoisRICARD-BLUM SylvieCALZOLAI LUIGI
Citation: BIOINTERPHASES vol. 11 no. 4 p. 04B310 -5
Publisher: AMER INST PHYSICS
Publication Year: 2016
JRC N°: JRC98173
ISSN: 1934-8630
URI: http://dx.doi.org/10.1116/1.4972113
http://publications.jrc.ec.europa.eu/repository/handle/JRC98173
DOI: 10.1116/1.4972113
Type: Articles in periodicals and books
Abstract: Ultraviolet (UV) radiation, temperature, and time can degrade proteins. Here we show that gold nanoparticles significantly protect human serum albumin (HSA) from denaturation when exposed to “stressing” conditions such as UV irradiation and sustained exposure in sub-optimal conditions. In particular, we show that gold nanoparticles significantly reduce the decrease in secondary structure induced by UV irradiation or extended exposure to ambient temperature.
JRC Directorate:Health, Consumers and Reference Materials

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