Title: The MARINA Risk Assessment Strategy: A Flexible Strategy for Efficient Information Collection and Risk Assessment of Nanomaterials
Authors: BOS Peter M. J.GOTTARDO STEFANIASCOTT-FORDSMAND JaneckVAN TONGEREN MartieSEMENZIN ElenaFERNANDES Teresa F.HRISTOZOV DanailHUND-RINKE K.HUNT NeilIRFAN Muhammad-AdeelLANDSIEDEL RobertPEIJNENBURG WillieSÁNCHEZ JIMÉNEZ AraceliVAN KESTEREN PetraOOMEN Agnes
Citation: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH vol. 12 no. 12 p. 15007-15021
Publisher: MDPI AG
Publication Year: 2015
JRC N°: JRC98658
ISSN: 1660-4601
URI: http://www.mdpi.com/1660-4601/12/12/14961
http://publications.jrc.ec.europa.eu/repository/handle/JRC98658
DOI: 10.3390/ijerph121214961
Type: Articles in periodicals and books
Abstract: An engineered nanomaterial (ENM) may actually consist of a population of primary particles, aggregates and agglomerates of various sizes. Furthermore, their physico-chemical characteristics may change during the various life-cycle stages. It will probably not be feasible to test all varieties of all ENMs for possible health and environmental risks. There is therefore a need to further develop the approaches for risk assessment of ENMs. Within the EU FP7 project Managing Risks of Nanoparticles (MARINA) a two-phase risk assessment strategy has been developed. In Phase 1 (Problem framing) a base set of information is considered, relevant exposure scenarios (RESs) are identified and the scope for Phase 2 (Risk assessment) is established. The relevance of an RES is indicated by information on exposure, fate/kinetics and/or hazard; these three domains are included as separate pillars that contain specific tools. Phase 2 consists of an iterative process of risk characterization, identification of data needs and integrated collection and evaluation of data on the three domains, until sufficient information is obtained to conclude on possible risks in a RES. Only data are generated that are considered to be needed for the purpose of risk assessment. A fourth pillar, risk characterization, is defined and it contains risk assessment tools. This strategy describes a flexible and efficient approach for data collection and risk assessment which is essential to ensure safety of ENMs. Further developments are needed to provide guidance and make the MARINA Risk Assessment Strategy operational. Case studies will be needed to refine the strategy.
JRC Directorate:Institute for Health and Consumer Protection Historical Collection

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