@book{JRC32513,
	editor = {},
	address = {},
	year = {2005},
	author = {Bouhifd M and Whelan M and Aprahamian M},
	isbn = {},
	abstract = {A novel prototype instrument for mutli-spectral imaging applications is described. The device is based on an acousto-optic tuneable filter (AOTF) that can be easily attached to many standard imaging systems (e.g. endoscope or fluorescence microscope). The instrument developed offers significant advantages over typical fixed-filter based systems in terms of flexibility, performance and diagnostic potential. The selected AOTF was designed to have a large acceptance aperture suitable for imaging applications. Any filtering centre-wavelength in the visible range (450 to 700nm) can be rapidly selected by either random access or by continuous tuning thus providing a versatile performance. The prototype instrument has been demonstrated for in-vivo applications where it was attached to the eyepiece of a commercial endoscope allowing simultaneous white light and fluorescence endoscopy. Autofluorescence of endogenous protoporphyrin IX (PpIX), a biomarker of diseased tissues undergoing an inflammatory response, was mapped in vivo on a rat model. The AOTF device was also coupled to the viewing port of a commercial fluorescence microscope thus realising a powerful fluorescence imaging spectrometer capable of detecting and mapping fluorescent biomolecules in vitro. 
		
		},
	title = {Fluorescence Imaging Spectroscopy Utilising Acousto-Optic Tuneable Filters},
	url = {},
	volume = {},
	number = {},
	journal = {},
	pages = {185-193},
	issn = {},
	publisher = {SPIE - The International Society for Optical Engineering},
	doi = {}
}