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dc.contributor.authorFERNANDO Ruani N.en_GB
dc.contributor.authorCHAUDHARI Umeshen_GB
dc.contributor.authorESCHER Sylvia E.en_GB
dc.contributor.authorHENGSTLER Janen_GB
dc.contributor.authorHESCHELER Juergenen_GB
dc.contributor.authorJENNINGS Paulen_GB
dc.contributor.authorKEUN Hector C.en_GB
dc.contributor.authorKLEINJANS Josen_GB
dc.contributor.authorKOLDE Raivoen_GB
dc.contributor.authorKOLLIPARA Laxmikanthen_GB
dc.contributor.authorKOPP-SCHNEIDER Annetteen_GB
dc.contributor.authorLIMONCIEL Aliceen_GB
dc.contributor.authorNEMADE Harshalen_GB
dc.contributor.authorNGUEMO Filomainen_GB
dc.contributor.authorPETERSON Hedien_GB
dc.contributor.authorPRIETO PERAITA Maria Del Pilaren_GB
dc.contributor.authorRODRIGUES Robimen_GB
dc.contributor.authorSACHINIDIS Agapiosen_GB
dc.contributor.authorSCHAEFER Christophen_GB
dc.contributor.authorSICKMANN Alberten_GB
dc.contributor.authorSPITKOVSKY Dimitryen_GB
dc.contributor.authorSTOEBER Reginaen_GB
dc.contributor.authorVAN BREDA Simoneen_GB
dc.contributor.authorVAN DE WATER Boben_GB
dc.contributor.authorVIVIER Manonen_GB
dc.contributor.authorZAHEDI René P.en_GB
dc.contributor.authorVINKEN Mathieuen_GB
dc.contributor.authorROGIERS Veraen_GB
dc.identifier.citationARCHIVES OF TOXICOLOGY. SUPPLEMENT. ARCHIV FÜR TOXIKOLOGIE. SUPPLEMENT vol. 90 no. 6 p. 1529-1539en_GB
dc.description.abstractSEURAT-1 is a joint research initiative between the European Commission and Cosmetics Europe aiming to develop in vitro- and in silico-based methods to replace the in vivo repeated dose systemic toxicity test used for the assessment of human safety. As one of the building blocks of SEURAT-1, the DETECTIVE project focused on a key element on which in vitro toxicity testing relies: the development of robust and reliable, sensitive and specific in vitro biomarkers and surrogate endpoints that can be used for safety assessments of chronically acting toxicants, relevant for humans. The work conducted by the DETECTIVE consortium partners has established a screening pipeline of functional and "-omics" technologies, including high-content and high-throughput screening platforms, to develop and investigate human biomarkers for repeated dose toxicity in cellular in vitro models. Identification and statistical selection of highly predictive biomarkers in a pathway- and evidence-based approach constitute a major step in an integrated approach towards the replacement of animal testing in human safety assessment. To discuss the final outcomes and achievements of the consortium, a meeting was organized in Brussels. This meeting brought together data-producing and supporting consortium partners. The presentations focused on the current state of ongoing and concluding projects and the strategies employed to identify new relevant biomarkers of toxicity. The outcomes and deliverables, including the dissemination of results in data-rich "-omics" databases, were discussed as were the future perspectives of the work completed under the DETECTIVE project. Although some projects were still in progress and required continued data analysis, this report summarizes the presentations, discussions and the outcomes of the project.en_GB
dc.description.sponsorshipJRC.I.5-Systems Toxicologyen_GB
dc.publisherSPRINGER VERLAGen_GB
dc.title“Watching the Detectives” report of the general assembly of the EU project DETECTIVE Brussels, 24–25 November 2015en_GB
dc.typeArticles in periodicals and booksen_GB
JRC Directorate:Institute for Health and Consumer Protection Historical Collection

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