Title: pH-sensitive niosomes: Effects on cytotoxicity and on inflammation and pain in murine models
Authors: RINALDI FEDERICADEL FAVERO ELENARONDELLI VALERIAPIERETTI STEFANOBOGNI ALESSIAPONTI JESSICAROSSI FRANCOISDI MARZIO LUISAPAOLINO DONATELLAMARIANECCI CARLOTTACARAFA MARIA
Citation: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY vol. 32 no. 1 p. 538-546
Publisher: TAYLOR & FRANCIS LTD
Publication Year: 2016
JRC N°: JRC101534
ISSN: 1475-6366
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC101534
DOI: 10.1080/14756366.2016.1268607
Type: Articles in periodicals and books
Abstract: pH-sensitive nonionic surfactant vesicles (niosomes) by polysorbate-20 (Tween-20) or polysorbate-20 derivatized by glycine (added as pH sensitive agent), were developed to deliver Ibuprofen (IBU) and Lidocaine (LID). For the physical-chemical characterization of vesicles (mean size, size distribution, zeta potential, vesicle morphology, bilayer properties and stability) dynamic light scattering (DLS), small angle X-ray scattering and fluorescence studies were performed. Potential cytotoxicity was evaluated on immortalized human keratinocyte cells (HaCaT) and on immortalized mouse fibroblasts Balb/3T3. In vivo antinociceptive activity (formalin test) and anti-inflammatory activity tests (paw edema induced by zymosan) in murine models were performed on drug-loaded niosomes. pH-sensitive niosomes were stable in the presence of 0 and 10% fetal bovine serum, non-cytotoxic and able to modify IBU or LID pharmacological activity in vivo. The synthesis of stimuli responsive surfactant, as an alternative to add pH-sensitive molecules to niosomes, could represent a promising delivery strategy for anesthetic and anti-inflammatory drugs.
JRC Directorate:Health, Consumers and Reference Materials

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