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|Title:||pH-sensitive niosomes: Effects on cytotoxicity and on inflammation and pain in murine models|
|Authors:||RINALDI FEDERICA; DEL FAVERO ELENA; RONDELLI VALERIA; PIERETTI STEFANO; BOGNI ALESSIA; PONTI JESSICA; ROSSI FRANCOIS; DI MARZIO LUISA; PAOLINO DONATELLA; MARIANECCI CARLOTTA; CARAFA MARIA|
|Citation:||JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY vol. 32 no. 1 p. 538-546|
|Publisher:||TAYLOR & FRANCIS LTD|
|Type:||Articles in periodicals and books|
|Abstract:||pH-sensitive nonionic surfactant vesicles (niosomes) by polysorbate-20 (Tween-20) or polysorbate-20 derivatized by glycine (added as pH sensitive agent), were developed to deliver Ibuprofen (IBU) and Lidocaine (LID). For the physical-chemical characterization of vesicles (mean size, size distribution, zeta potential, vesicle morphology, bilayer properties and stability) dynamic light scattering (DLS), small angle X-ray scattering and fluorescence studies were performed. Potential cytotoxicity was evaluated on immortalized human keratinocyte cells (HaCaT) and on immortalized mouse fibroblasts Balb/3T3. In vivo antinociceptive activity (formalin test) and anti-inflammatory activity tests (paw edema induced by zymosan) in murine models were performed on drug-loaded niosomes. pH-sensitive niosomes were stable in the presence of 0 and 10% fetal bovine serum, non-cytotoxic and able to modify IBU or LID pharmacological activity in vivo. The synthesis of stimuli responsive surfactant, as an alternative to add pH-sensitive molecules to niosomes, could represent a promising delivery strategy for anesthetic and anti-inflammatory drugs.|
|JRC Directorate:||Health, Consumers and Reference Materials|
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