Towards a 21st-century roadmap for biomedical research and drug discovery: Consensus report and recommendations

Decades of costly failures in translating drug candidates from preclinical disease models to human therapeutic use warrant reconsideration of the priority placed on animal models in biomedical research. Following an international workshop attended by experts from academia, government institutions, research funding bodies and the corporate and NGO sectors, this consensus report analyses, as case studies, five disease areas with major unmet needs for new treatments. In view of the scientifically driven transition towards a human pathways-based paradigm in toxicology, a similar paradigm shift appears to be justified in biomedical research. There is a pressing need for an approach that strategically implements advanced, human biology-based models and tools to understand disease pathways at multiple biological scales. We present recommendations to help achieve this.

LANGLEY Gill;  ADCOCK Ian;  BUSQUET Francois;  CSERNOK Elena;  GIESE Christoph;  HERRMANN Kathrin;  LANDESMANN Brigitte;  MARSHALL Lindsay;  MCIVOR Emily;  MUOTRI Alysson R.;  NOOR Fozia;  SCHUTTE Katrin;  SEIDLE Troy;  VAN DE STOLPE Anja;  VAN ESCH Hilde;  WILLETT Catherine;  WOSZCZEK Grzegorz; 

2016-12-22

ELSEVIER BV

JRC102475

1740-6757,   

https://publications.jrc.ec.europa.eu/repository/handle/JRC102475,   

10.1016/j.drudis.2016.10.011,