Title: In vitro genotoxicity testing – can the performance be enhanced?
Authors: CORVI RAFFAELLAMADIA FEDERICA
Citation: FOOD AND CHEMICAL TOXICOLOGY vol. 106 no. Part B p. 600-608
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Publication Year: 2016
JRC N°: JRC102596
ISSN: 0278-6915
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC102596
DOI: 10.1016/j.fct.2016.08.024
Type: Articles in periodicals and books
Abstract: The assessment of genotoxicity represents an essential component of the safety assessment of all types of substances. Several in vitro tests are available at different stages of development and acceptance, yet they are not considered at present sufficient to fully replace animal tests needed to evaluate the safety of substances. For an overall improvement of the traditional genotoxicity testing paradigm several recent activities have taken place. These include the improvement of existing tests, the development of novel tests, as well as, the establishment and exploration of approaches to optimise in vitro testing accuracy. Furthermore, useful tools, such as databases or reference chemical list have been developed to support advances in this field.
JRC Directorate:Health, Consumers and Reference Materials

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