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|Title:||Chapter 6 Validation of Computational Methods|
|Authors:||Patlewicz Grace; WORTH Andrew; BALL Nicholas|
|Type:||Articles in periodicals and books|
|Abstract:||In this chapter, we provide an overview of how (Quantitative) Structure Activity Relationships, (Q)SARs, are validated and applied for regulatory purposes. We outline how chemical categories are derived to facilitate endpoint specific readacross using tools such as the OECD QSAR Toolbox and discuss some of the current difficulties in addressing the residual uncertainties of read-across. Finally we put forward a perspective of how non-testing approaches may evolve in light of the advances in new and emerging technologies and how these fit within the Adverse Outcome Pathway (AOP) framework.|
|JRC Directorate:||Health, Consumers and Reference Materials|
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