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dc.contributor.authorWORTH Andrewen_GB
dc.contributor.authorPatlewicz Graceen_GB
dc.date.accessioned2016-10-29T00:21:06Z-
dc.date.available2016-10-27en_GB
dc.date.available2016-10-29T00:21:06Z-
dc.date.created2016-10-24en_GB
dc.date.issued2016en_GB
dc.date.submitted2016-09-09en_GB
dc.identifier.isbn978-3-319-33824-8en_GB
dc.identifier.issn0065-2598en_GB
dc.identifier.urihttp://www.springer.com/series/5584en_GB
dc.identifier.urihttp://publications.jrc.ec.europa.eu/repository/handle/JRC103063-
dc.description.abstractIn this chapter, we explain how Integrated Approaches to Testing and Assessment (IATA) offer a means of integrating and translating the data generated by toxicity testing methods, thereby serving as flexible and suitable tools for toxicological decision making in the twenty-first century. In addition to traditional in vitro and in vivo testing methods, IATA are increasingly incorporating newly developed in vitro systems and measurement technologies such as high throughput screening and high content imaging. Computational approaches are also being used in IATA development, both as a means of generating data (e.g. QSARs), interpreting data (bioinformatics and chemoinformatics), and as a means of integrating multiple sources of data (e.g. expert systems, bayesian models). Decision analytic methods derived from socioeconomic theory can also play a role in developing flexible and optimal IATA solutions. Some of the challenges involved in the development, validation and implementation of IATA are also discussed.en_GB
dc.description.sponsorshipJRC.F.3-Chemicals Safety and Alternative Methodsen_GB
dc.format.mediumPrinteden_GB
dc.languageENGen_GB
dc.publisherSpringeren_GB
dc.relation.ispartofseriesJRC103063en_GB
dc.titleChapter 13; Integrated Approaches to Testing and Assessmenten_GB
dc.typeArticles in periodicals and booksen_GB
dc.identifier.doi10.1007/978-3-319-33826-2en_GB
JRC Directorate:Health, Consumers and Reference Materials

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