Title: Including Non-Dietary Sources into an Exposure Assessment of the European Food Safety Authority: the challenge of multi-sector chemicals such as Bisphenol A
Authors: VON GOETZ NATALIEPIROW RALPHHART ANDREWBRADLEY EMMAPOCAS MARIA DE FATIMAARCELLA DAVIDELILLEGARD ITLSIMONEAU CATHERINEVAN ENGELEN JACQUELINEHUSOY TRINETHEOBALD ANNELECLERCQ CATHERINE
Citation: REGULATORY TOXICOLOGY AND PHARMACOLOGY vol. Volume 85 no. April 2017 p. Pages 70–78
Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE
Publication Year: 2016
JRC N°: JRC104731
ISSN: 0273-2300
URI: http://dx.doi.org/10.1016/j.yrtph.2017.02.004
http://publications.jrc.ec.europa.eu/repository/handle/JRC104731
DOI: 10.1016/j.yrtph.2017.02.004
Type: Articles in periodicals and books
Abstract: In the most recent risk assessment for Bisphenol A for the first time a multi-route aggregate exposure assessment was conducted by the European Food Safety Authority. This assessment includes exposure via dietary sources, and also contributions of the most important non-dietary sources. Both average and high aggregate exposure were calculated by source-to-dose modeling (forward calculation) for different age groups and compared with estimates based on urinary biomonitoring data (backward calculation). The aggregate exposure estimates obtained by forward and backward modeling are in the same order of magnitude, with forward modeling yielding higher estimates associated with larger uncertainty. Yet, only forward modeling can indicate the relative contribution of different sources. Dietary exposure, especially via canned food, appears to be the most important exposure source and, based on the central exposure estimates, contributes around 90% to internal exposure to total (conjugated plus unconjugated) BPA. Dermal exposure via thermal paper and to a lesser extent via cosmetic products may contribute around 10% (central estimate) for some age groups. The uncertainty around these estimates is considerable, but since after dermal absorption a first-pass metabolism of BPA by glucuronidation is lacking, dermal sources may be of equal or even higher toxicological relevance than dietary sources.
JRC Directorate:Health, Consumers and Reference Materials

Files in This Item:
There are no files associated with this item.


Items in repository are protected by copyright, with all rights reserved, unless otherwise indicated.