Title: Preclinical evaluation of anti-HER2 2Rs15d nanobody labeled with 225Ac
Authors: PRUSZYNSKI MAREKD’HUYVETTER MATTHIASCĘDROWSKA ELAHOUTTE TONYBRUCHERTSEIFER FRANKMORGENSTERN ALFRED
Publisher: European Commission - Joint Research Centre
Publication Year: 2017
JRC N°: JRC105962
URI: http://nucmed.w3.kanazawa-u.ac.jp/symposium/tat10/
http://publications.jrc.ec.europa.eu/repository/handle/JRC105962
Type: Articles in periodicals and books
Abstract: Human Epidermal Growth Factor Receptor type 2 (HER2) is overexpressed in a series of human cancer types such as breast, ovarian, colorectal and urothelial carcinomas and is often associated with a higher recurrence rate and a shorter time to relapse. Intact mAbs are not always ideal vectors for radioimmunotherapy due to their slow pharmacokinetic and normal-tissue clearance. Nanobodies (nbs) are small antibody fragments (~15kDa) with beneficial pharmacokinetic properties, and those targeted to HER2 are very attractive vectors for targeted radionuclide therapy (TRT). The aim of this study was to develop and evaluate a potential molecular-targeted drug based on the anti-HER2-Nb labeled with 225Ac
JRC Directorate:Nuclear Safety and Security

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