Title: 225Ac-PSMA617: PSMA targeting alpha-radiation therapy of patients with mCRPC
Authors: KRATOCHWIL CLEMENSBRUCHERTSEIFER FRANKGIESEL FREDERIKAPOSTOLIDIS CHRISTOSHABERKORN UWEMORGENSTERN ALFRED
Publisher: European Commission - Joint Research Centre
Publication Year: 2017
JRC N°: JRC106148
URI: http://nucmed.w3.kanazawa-u.ac.jp/symposium/tat10/
http://publications.jrc.ec.europa.eu/repository/handle/JRC106148
Type: Articles in periodicals and books
Abstract: To evaluate the potential of PSMA targeting 225Ac-PSMA617 as a promising new treatment option for poor prognosis advanced stage mCRPC (metastatic castration-resistant prostate cancer) patients. An appropriate starting activity for clinical application of 225Ac-PSMA617 was defined by preliminary dosimetry modeling. The treatment protocol was further refined by an empirical dose escalation during “compassionate use” in a first group of advanced stage patients. The derived “standard operation procedure” was used to treat a larger group of patients, which now has >6 months of follow up. Here we report our clinical observations in regard to anti-tumor activity as well as acute and mid-term toxicities experienced with this new concept of mCRPC therapy.
JRC Directorate:Nuclear Safety and Security

Files in This Item:
There are no files associated with this item.


Items in repository are protected by copyright, with all rights reserved, unless otherwise indicated.