Title: Correspondence between alpha-particle emitter dosimetry and normal organ toxicity
Authors: JOSEFSSON ANDERSNEDROW JESSIEHOBBS ROBERT F.BAECK TOMPARK SUNJUBRUCHERTSEIFER FRANKMORGENSTERN ALFREDSGOUROS GEORGE
Publisher: European commision - Joint Research Centre
Publication Year: 2017
JRC N°: JRC106151
URI: http://nucmed.w3.kanazawa-u.ac.jp/symposium/tat10/
http://publications.jrc.ec.europa.eu/repository/handle/JRC106151
Type: Articles in periodicals and books
Abstract: The objective of dosimetry is to guide the design and implementation of radiopharmaceutical therapy, either on a patient population basis, or if the variability is sufficiently high, on an individual patient basis. Key to this is that absorbed dose estimates predict likely toxicity and tumor response to treatment. It is not possible to administer a tracer level of activity in alpha-particle emitter therapy to obtain the pharmacokinetics required for dosimetry, therefore, preclinical microscale dosimetry studies must be combined with macroscopic whole-organ dosimetry. We illustrate this approach for an antibody that targets the immune checkpoint inhibitor, PD-L1 which we have investigated as a means of alpha-particle emitter delivery in a combined immunological and alpha-particle emitter targeting strategy.
JRC Directorate:Nuclear Safety and Security

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