Title: Targeted alpha therapy of glioblastoma multiforme: clinical experience with 213Bi- and 225Ac-Substance P
Authors: KROLICKI LESZEKBRUCHERTSEIFER FRANKKUNIKOWSKA JOLANTAKOZIARA HKROLICKI BJAKUCINSKI MPAWLAK DARIUSZAPOSTOLIDIS CHRISTOSROLA RMERLO A.MORGENSTERN ALFRED
Publisher: European Commission - Joint Research Centre
Publication Year: 2017
JRC N°: JRC106153
URI: http://nucmed.w3.kanazawa-u.ac.jp/symposium/tat10/
http://publications.jrc.ec.europa.eu/repository/handle/JRC106153
Type: Articles in periodicals and books
Abstract: Glioblastoma multiforme (GBM), the most common primary brain tumor in adults, has a very poor prognosis with a median overall survival of 14.6 months despite of aggressive therapy. Targeted alpha therapy (TAT) with the short range, high LET alpha emitters 213Bi and 225Ac offers the potential for selective irradiation of tumors and minimizing damage to adjacent regions of the brain. The low-molecular weight peptide carrier substance P is targeting NK 1 receptors, which are consistently over-expressed on GBM cells. We report our clinical experience with 213Bi-DOTA-Substance P (213Bi-SP) and 225Ac-DOTAGA-Substance P (225Ac-SP) in patients with recurrent GBM.
JRC Directorate:Nuclear Safety and Security

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