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|Title:||Bi-213-anti-EGFR-MAb therapy of recurrent bladder cancer – a pilot study|
|Authors:||SCHEIDHAUER KLEMENS; SEIDL C.; BRUCHERTSEIFER FRANK; APOSTOLIDIS CHRISTOS; AUTENRIETH MICHAEL; KURTZ F; HORN THOMAS; SCHWAIGER MARKUS; GSCHWEND J.E.; D'ALESSANDRIA C; PFOB C; SENEKOWITSCH-SCHMIDTKE REINGARD; MORGENSTERN ALFRED|
|Publisher:||European Commission - Joint Resarch Centre|
|Type:||Articles in periodicals and books|
|Abstract:||Following transurethral resection of non-muscle-invasive bladder cancer (carcinoma in situ) and subsequent chemotherapy and treatment with Bacillus Calmette–Guérin (BCG), up to 40% of patients relapse within 5 years and need complete bladder excision. Therefore, new therapeutic strategies to combat tumor recurrence are needed. Because treatment of mice bearing intravesical human bladder cancer xenografts with Bi-213-anti-EGFR-MAb turned out highly efficient, the aim of this pilot study was to evaluate feasibility, safety and therapeutic efficacy of the α-emitter radioimmunoconjugate in recurrent bladder cancer patients.|
|JRC Directorate:||Nuclear Safety and Security|
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