Title: Non-equivalence of different evaluation algorithms to derive mean particle size from dynamic light scattering data
Citation: JOURNAL OF NANOPARTICLE RESEARCH vol. 21 no. 195 p. 1-10
Publisher: SPRINGER
Publication Year: 2019
JRC N°: JRC106171
ISSN: 1388-0764 (online)
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC106171
DOI: 10.1007/s11051-019-4630-2
Type: Articles in periodicals and books
Abstract: Various evaluation algorithms are implemented by different manufacturers of dynamic light scattering (DLS) instruments. Users often implicitly assume that the results from the various algorithms are equivalent. This hypothesis was tested using polystyrene latex nanomaterials and two moderately polydisperse silica nanomaterials. Materials were tested in-house using different DLS evaluation algorithms. In addition, the results of an interlaboratory comparison were checked for any indication of the influence of the algorithm. The average particle diameter differed significantly only in few cases between algorithms. Precision, both within-laboratory as well as between-laboratory, was strongly influenced by the algorithm, especially for the more polydisperse silica materials. Results obtained by the cumulants method usually showed the best repeatability and lowest between-laboratory standard deviation. Finally, the results of conversion of the intensity-weighted mean to the volume-weighted mean value were investigated using the data from the intercomparison. The results confirm the theoretical expectations that conversion increases the variation significantly.
JRC Directorate:Health, Consumers and Reference Materials

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