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|Title:||Quantitative structure-skin permeability relationships|
|Authors:||TSAKOVSKA IVANKA; PAJEVA ILZA; AL SHARIF MERILIN; ALOV PETKO; FIORAVANZO ELENA; KOVARICH SIMONA; WORTH ANDREW; RICHARZ ANDREA; YANG CHIHAE; MOSTRAG-SZLICHTYNG A.; CRONIN MARK|
|Citation:||TOXICOLOGY vol. 387 p. 27-42|
|Publisher:||ELSEVIER IRELAND LTD|
|Type:||Articles in periodicals and books|
|Abstract:||This paper reviews in silico models currently available for the prediction of skin permeability. A comprehensive discussion on the developed methods is presented, focusing on quantitative structure-permeability relationships. In addition, the mechanistic models and comparative studies that analyse different models are discussed. Limitations and strengths of the different approaches are highlighted together with the emergent issues and perspectives.|
|JRC Directorate:||Health, Consumers and Reference Materials|
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