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dc.contributor.authorMYATT GLENNen_GB
dc.contributor.authorAHLBERG ERNSTen_GB
dc.contributor.authorAKAHORI YUMIen_GB
dc.contributor.authorALLEN DAVIDen_GB
dc.contributor.authorAMBERG ALEXANDERen_GB
dc.contributor.authorANGER LENNART Ten_GB
dc.contributor.authorAPTULA AYNURen_GB
dc.contributor.authorAUERBACH SCOTTen_GB
dc.contributor.authorBEILKE LISA D.en_GB
dc.contributor.authorBELLION PHILLIPen_GB
dc.contributor.authorBENIGNI ROMUALDOen_GB
dc.contributor.authorBERCU JOELen_GB
dc.contributor.authorBOOTH EWAN Den_GB
dc.contributor.authorBOWER DAVEen_GB
dc.contributor.authorBRIGO ALESSANDROen_GB
dc.contributor.authorBURDEN NATALIEen_GB
dc.contributor.authorCAMMERER ZORYANAen_GB
dc.contributor.authorCRONIN MARKen_GB
dc.contributor.authorCROSS KEVIN P.en_GB
dc.contributor.authorCUSTER LAURAen_GB
dc.contributor.authorDETTWILER MAGDALENAen_GB
dc.contributor.authorDOBO KRISTAen_GB
dc.contributor.authorFORD KEVIN A.en_GB
dc.contributor.authorFORTIN MARI Cen_GB
dc.contributor.authorGAD-MCDONALD SAMANTHA Een_GB
dc.contributor.authorGELLATLY NICHOLAen_GB
dc.contributor.authorGERVAIS VÉRONIQUEen_GB
dc.contributor.authorGLOVER KYLE Pen_GB
dc.contributor.authorGLOWIENKE SUSANNEen_GB
dc.contributor.authorVAN GOMPEL JACKYen_GB
dc.contributor.authorGUTSELL STEVEen_GB
dc.contributor.authorHARDY BARRYen_GB
dc.contributor.authorHARVEY JAMESen_GB
dc.contributor.authorHILLEGASS JEDDen_GB
dc.contributor.authorHONMA MASAMITSUen_GB
dc.contributor.authorHSIEH JUI-HUAen_GB
dc.contributor.authorHSU CHIA-WENen_GB
dc.contributor.authorHUGHES KATHYen_GB
dc.contributor.authorJOHNSON CANDICEen_GB
dc.contributor.authorJOLLY ROBERTen_GB
dc.contributor.authorJONES DAVIDen_GB
dc.contributor.authorKEMPER RAYen_GB
dc.contributor.authorKENYON MICHELLEen_GB
dc.contributor.authorKIM MARLENE Ten_GB
dc.contributor.authorKRUHLAK NAOMIen_GB
dc.contributor.authorKULKARNI SUNIL Aen_GB
dc.contributor.authorKUEMMERER KLAUSen_GB
dc.contributor.authorLEAVITT PENNYen_GB
dc.contributor.authorMAJER BERNHARDen_GB
dc.contributor.authorMASTEN SCOTTen_GB
dc.contributor.authorMILLER SCOTTen_GB
dc.contributor.authorMOSER JANETen_GB
dc.contributor.authorMUMTAZ MOIZen_GB
dc.contributor.authorMUSTER WOLFGANGen_GB
dc.contributor.authorNEILSON LOUISEen_GB
dc.contributor.authorOPREA TUDOR L.en_GB
dc.contributor.authorPATLEWICZ GRACEen_GB
dc.contributor.authorPAULINO ALEXANDREen_GB
dc.contributor.authorLO PIPARO ELENAen_GB
dc.contributor.authorPOWLEY MARKen_GB
dc.contributor.authorQUIGLEY DONALD P.en_GB
dc.contributor.authorREDDY M VIJAYARAJen_GB
dc.contributor.authorRICHARZ ANDREAen_GB
dc.contributor.authorRUIZ PATRICIAen_GB
dc.contributor.authorSCHILTER BENOÎTen_GB
dc.contributor.authorSERAFIMOVA ROSITSAen_GB
dc.contributor.authorSIMPSON WENDYen_GB
dc.contributor.authorSTAVITSKAYA LIDIYAen_GB
dc.contributor.authorSTIDL REINHARDen_GB
dc.contributor.authorSUAREZ-RODRIGUEZ DIANAen_GB
dc.contributor.authorSZABO DAVID Ten_GB
dc.contributor.authorTEASDALE ANDREWen_GB
dc.contributor.authorTREJO-MARTIN ALEJANDRAen_GB
dc.contributor.authorVALENTIN JEAN-PIERREen_GB
dc.contributor.authorVUORINEN ANNAen_GB
dc.contributor.authorWALL BRIAN Aen_GB
dc.contributor.authorWATTS PETEen_GB
dc.contributor.authorWHITE ANGELAen_GB
dc.contributor.authorWICHARD JOERGen_GB
dc.contributor.authorWITT KRISTINEen_GB
dc.contributor.authorWOOLLEY ADAMen_GB
dc.contributor.authorWOOLLEY DAVIDen_GB
dc.contributor.authorZWICKL CRAIGen_GB
dc.contributor.authorHASSELGREN CATRINen_GB
dc.date.accessioned2018-05-26T00:04:29Z-
dc.date.available2018-05-24en_GB
dc.date.available2018-05-26T00:04:29Z-
dc.date.created2018-05-18en_GB
dc.date.issued2018en_GB
dc.date.submitted2017-07-12en_GB
dc.identifier.citationREGULATORY TOXICOLOGY AND PHARMACOLOGY vol. 96 p. 1-17en_GB
dc.identifier.issn0273-2300en_GB
dc.identifier.urihttp://publications.jrc.ec.europa.eu/repository/handle/JRC107447-
dc.description.abstractThe present publication surveys several applications of in silico (i.e., computational) toxicology approaches across different industries and institutions. It highlights the need to develop standardized protocols when conducting toxicity-related predictions. This contribution articulates the information needed for protocols to support in silico predictions for major toxicological endpoints of concern (e.g., genetic toxicity, carcinogenicity, acute toxicity, reproductive toxicity, developmental toxicity) across several industries and regulatory bodies. Such novel in silico toxicology (IST) protocols, when fully developed and implemented, will ensure in silico toxicological assessments are performed and evaluated in a consistent, reproducible, and well-documented manner across industries and regulatory bodies to support wider uptake and acceptance of the approaches. The development of IST protocols is an initiative developed through a collaboration among an international consortium to reflect the state-of-the-art in in silico toxicology for hazard identification and characterization. A general outline for describing the development of such protocols is included and it is based on in silico predictions and/or available experimental data for a defined series of relevant toxicological effects or mechanisms. The publication presents a novel approach for determining the reliability of in silico predictions alongside experimental data. In addition, we discuss how to determine the level of confidence in the assessment based on the relevance and reliability of the information.en_GB
dc.description.sponsorshipJRC.F.3-Chemicals Safety and Alternative Methodsen_GB
dc.format.mediumOnlineen_GB
dc.languageENGen_GB
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCEen_GB
dc.relation.ispartofseriesJRC107447en_GB
dc.titleIn silico toxicology protocolsen_GB
dc.typeArticles in periodicals and booksen_GB
dc.identifier.doi10.1016/j.yrtph.2018.04.014en_GB
JRC Directorate:Health, Consumers and Reference Materials

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