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|Title:||Applying ‘omics technologies in chemicals risk assessment: report of an ECETOC workshop|
|Authors:||BUESEN ROLAND; CHORLEY BRIAN N; DA SILVA LIMA BEATRIZ; DASTON GEORGE; DEFERME LIZE; EBBELS TIMOTHY; GANT TIMOTHY W; GOETZ AMBER; GREALLY JOHN; GRIBALDO LAURA; HACKERMUELLER JOERG; HUBESCH BRUNO; JENNEN DANYEL G.J.; JOHNSON KAMIN; KANNO JUN; KAUFFMANN HANS-MARTIN; LAFFONT MADELEINE; MCMULLEN PATRICK; MEEHAN RICHARD; PEMBERTON MARK; PERDICHIZZI STEFANIA; PIERSMA ALDERT; SAUER URSULA; SCHMIDT KERSTIN; SEITZ HERVE; SUMIDA KAYO; TOLLEFSEN KNUT ERIK; TONG WEIDA; TRALAU TEWES; VAN RAVENZWAAY BENNARD; WEBER RALF; WORTH ANDREW; YAUK CAROLE L; POOLE ALAN|
|Citation:||REGULATORY TOXICOLOGY AND PHARMACOLOGY vol. 91 p. S3-S13|
|Publisher:||ACADEMIC PRESS INC ELSEVIER SCIENCE|
|Type:||Articles in periodicals and books|
|Abstract:||Prevailing knowledge gaps in linking specific molecular changes to apical outcomes and methodological uncertainties in the generation, storage, processing, and interpretation of 'omics data limit the application of 'omics technologies in regulatory toxicology. Against this background, the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) convened a workshop Applying 'omics technologies in chemicals risk assessment that is reported herein. Ahead of the workshop, multi-expert teams drafted frameworks on best practices for (i) a Good-Laboratory Practice-like context for collecting, storing and curating 'omics data; (ii) the processing of 'omics data; and (iii) weight-of-evidence approaches for integrating 'omics data. The workshop participants confirmed the relevance of these Frameworks to facilitate the regulatory applicability and use of 'omics data, and the workshop discussions provided input for their further elaboration. Additionally, the key objective (iv) to establish approaches to connect 'omics perturbations to phenotypic alterations was addressed. Generally, it was considered promising to strive to link gene expression changes and pathway perturbations to the phenotype by mapping them to specific adverse outcome pathways. While further work is necessary before gene expression changes can be used to establish safe levels of substance exposure, the ECETOC workshop provided important incentives towards achieving this goal.|
|JRC Directorate:||Health, Consumers and Reference Materials|
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